You can set up either horizontal or vertical guides by going to the "View" menu and then selecting New Guide. Here you are give the choice of vertical and horizontal and you can set them either numerically or you can just drag them into place.
Under the Edit>preferences menu you can select the color used for the guide. I don't believe you can have different colored guides in one doent--I think the choice of color affects all guides in the doent.
You can than save your doent as a particular guide layout for future use.