Your question is pretty vague. You'll probably want to have at least coldfusion
MX running. Before that xml wasn't easily parsed. Here are some suggestion.

<cffile action="read" file="#pathtofile#" variable="myXml">
<!--- <cfhttp url="#urltofile#" method="get" timeout="30">
<cfset myXml=cfhttp.filecontent>
I didn't check my code so some of these attributes might not be correct
--->

<cfset parsedxml=xmlparse(myXml)>

<cfdump var="#parsedxml#">
<!--- this will give you the structures --->
Then call them like any other structure.
<cfoutput>#struct1.nestedstruct2.nestedstruct3.xml text#</cfoutput>
Or if there are multiple instances of nestedstruct3
<cfoutput>#struct1.nestedstruct2.nestedstruct3[instancenum].xmltext#</cfoutput>